[Becky]

Dear Amanda

I know you are disappointed but wait and see what the PET scan says for certainty. What you have been on worked at least on some things so if you can't biopsy or get in a trial, add something to what you are already on? It is difficult from your signature to see if you are still on Herceptin - if not, ask to add that back in. Maybe it works on the lungs and everything else responds to what you're already on.

Sometimes we all might think if we have mets in different parts of the body (or several tumors in one part of the body) that all of those tumors are exactly the same as each other. But remember, they are cancer and cancer is a mutation and each may be a small nuance different from each other and mutating in different ways. Perhaps the lung mets hate Herceptin and respond but the skin could care less so.... If your lungs did well on Herceptin, add it back on top and see if these synergies do you some good since you have visually seen that what you are on DID do you some good. I am just thinking out loud here of course but it would be a shame to make a major change (without a nifty trial) when you got some good from this combo.

Love and hugs from me in NJ