HER2 Support Group Forums - View Single Post - Questions on how you feel on Lapatinib and Xeloda

Mandamoo · 03-04-2012, 04:14 PM

I am following with interest as i have just started this combination. I have had a week and a half of xeloda with no real side effects apart from slight fatigue but added tykerb into the mix three days ago. I have had diarrhea but only once a day so manageable but I feel very foggy and fatigued. I have lost my appetite too- a bit like early pregnancy. I am taking 5 tykerb in the morning and then 4 xeloda twice a day - breakfast and dinner. I have the option to reduce to 4 tykerb and 3 xeloda twice a day. I am going to give myself a bit of time to adjust as I am only day 3 on the Tykerb.
I will have a week off the xeloda after 2 weeks on. My fingers and toes are a little drier but ok so far but it is early days I suppose. I have seen my skin met almost disappear to a pale pink mark on my skin within a week of taking the xeloda so I am hopeful the addition of the tykerb will kick these lung mets away too.
I might try the tykerb at night and see if that makes a difference.

Does anyone know what the most effective doses are?
Thanks,
Amanda x

03-04-2012, 04:14 PM	#9
Mandamoo Senior Member Join Date: Jul 2011 Location: Melbourne, Australia Posts: 432	Re: Questions on how you feel on Lapatinib and Xeloda I am following with interest as i have just started this combination. I have had a week and a half of xeloda with no real side effects apart from slight fatigue but added tykerb into the mix three days ago. I have had diarrhea but only once a day so manageable but I feel very foggy and fatigued. I have lost my appetite too- a bit like early pregnancy. I am taking 5 tykerb in the morning and then 4 xeloda twice a day - breakfast and dinner. I have the option to reduce to 4 tykerb and 3 xeloda twice a day. I am going to give myself a bit of time to adjust as I am only day 3 on the Tykerb. I will have a week off the xeloda after 2 weeks on. My fingers and toes are a little drier but ok so far but it is early days I suppose. I have seen my skin met almost disappear to a pale pink mark on my skin within a week of taking the xeloda so I am hopeful the addition of the tykerb will kick these lung mets away too. I might try the tykerb at night and see if that makes a difference. Does anyone know what the most effective doses are? Thanks, Amanda x __________________ Amanda xx 40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11 Wife to my wonderfully supportive husband of 17 years! 22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old (L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins. Fec3, Taxotere and herceptin2 - stopped due to secondary diagnosis June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy! September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing. January 2013 - herceptin, carboplatin and Perjeta (compassionate access) April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.