HER2 Support Group Forums - View Single Post - HRT and ER-, PR-, Her2+ BC

Becky · 01-23-2016, 08:13 AM

That's a tough question. Some research says that all bc starts with estrogen excitation. The cancer then can mutate to find a way to grow best such as her2 or some other receptor such as triple negative. Many of the studies come from studying BRCA1. Women with BRCA1 tend to almost exclusively get triple negative cancer but they know that excitation from estrogen plays a huge role. Hence the study that BRCA1+ women are recommended to remove their ovaries as it reduces their chance of bc by 65% . Of course many of these women also remove their breasts but some try to keep them, at least temporarily for awhile.

I would discuss this with your gynecologist and perhaps an endocrinologist and get other opinions on this touchy issue.

01-23-2016, 08:13 AM	#2
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: HRT and ER-, PR-, Her2+ BC That's a tough question. Some research says that all bc starts with estrogen excitation. The cancer then can mutate to find a way to grow best such as her2 or some other receptor such as triple negative. Many of the studies come from studying BRCA1. Women with BRCA1 tend to almost exclusively get triple negative cancer but they know that excitation from estrogen plays a huge role. Hence the study that BRCA1+ women are recommended to remove their ovaries as it reduces their chance of bc by 65% . Of course many of these women also remove their breasts but some try to keep them, at least temporarily for awhile. I would discuss this with your gynecologist and perhaps an endocrinologist and get other opinions on this touchy issue. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"