Thanks to all for the answers.
I am quite please by this short survey (hope more replies to come).
Even if this is not a double blind clinical trial statistical results, one can be optimistic since of 7 women taking Herceptin & one aromatase inhibitor (5 on Arimidex,one on Faslodex,one on Femara) none has reported resistance & 2 (ROZ & Lisa) said they had fast & very good response to this combo.(one with Arimidex the other with Femara). These two cases of quick & strong response must be added to that of Taffy who was the trigger to this survey.
Also impressive is the variety of stages in which the combo works: both early non metastatic & later metastatic settings.
Those who are taking supplements such as fish oil seem to be OK
Mjo is not include in these figures as she just started on Arimidex
The other good news is the phenominally opportune scoop by snoopy in finding today's press release on the results of the clinical trial in Europe of the combo.
http://www.nelm.nhs.uk/Record%20View...aspx?id=565643
Roche announces results claiming trastuzumab combination with anastrozole increases progression-free survival for patients with advanced breast cancer. (Extract)
The TAnDEM study, conducted by Roche is a randomised, Phase III trial, which evaluated trastuzumab in combination with anastozole versus anastrozole alone as first-line therapy (or second line hormonal therapy) in 208 postmenopausal women with advanced (metastatic), HER2-positive and hormone receptor-positive (ER-positive and/or PR-positive) breast cancer. Patients received anastrozole at a dose of 1 mg daily until progression. Trastuzumab was administered in 2 mg/kg weekly doses (after an initial loading dose of 4 mg/kg) until disease progression.
This is not comparing Herceptin+Arimidex to Herceptin alone but it at least demonstrates that there is no antagonism between Herceptin & Arimidex ( which may be the case between Herceptin & Tamoxifen).
The press release has no details. Full reporting awaits the sept 29-oct3 2006 ESMO conference in Turkey.