HER2 Support Group Forums - View Single Post - HER2 and Immunotherapy Studies for reference

agness · 02-17-2016, 11:37 PM

Some of the immunotherapies are targeting hormonally positive BC patients at risk for having their cancer mutate to HER2+. I read somewhere, and this isn't exclusively true, that having a low PR positivity increases the risk of the cell line shifting to ER+/HER2+.

I think we need to understand the difference between the different types of immunotherapies too. They target different cancerous mutations or alter immune system behavior. Some work better with no known disease burden, some low disease burden and some seem to work even for late stage disease. They are still learning so much and so many immunotherapy drugs are still in lengthy trials which seems tons less based upon how well they work but more based upon popularity of the concept within the medical community and business market sadly. We need greater access.

02-17-2016, 11:37 PM	#25
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: HER2 and Immunotherapy Studies for reference Some of the immunotherapies are targeting hormonally positive BC patients at risk for having their cancer mutate to HER2+. I read somewhere, and this isn't exclusively true, that having a low PR positivity increases the risk of the cell line shifting to ER+/HER2+. I think we need to understand the difference between the different types of immunotherapies too. They target different cancerous mutations or alter immune system behavior. Some work better with no known disease burden, some low disease burden and some seem to work even for late stage disease. They are still learning so much and so many immunotherapy drugs are still in lengthy trials which seems tons less based upon how well they work but more based upon popularity of the concept within the medical community and business market sadly. We need greater access. __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.