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Re: TDM-1 side effects
Hi Kim - my response was not so intense. I am day 6 now. Crashed with extreme tiredness within hours of the first infusion, no appetite slight nausea and headache. Day 2 - very lethargic, headache. Day 3 - crashed with fatigue, headache, low grade temp, muscle aches. Day 4 headache and aches but up and about - low temp at night. Day 5 - pretty good but still taking paracetamol for aches in joints and muscles and headache, afternoon rest. Day 6 - so far so good - don't feel normal (!) but ok so far.
I have lung mets - I've felt nothing alarming but have had slight chest heaviness but I also have a viral infection so who knows?
I hope the next one is better for you.
__________________
Amanda xx
40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11
Wife to my wonderfully supportive husband of 17 years!
22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old
(L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins.
Fec*3, Taxotere and herceptin*2 - stopped due to secondary diagnosis
June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions
Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo
February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again
August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy!
September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing.
January 2013 - herceptin, carboplatin and Perjeta (compassionate access)
April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta
July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.
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