HER2 Support Group Forums - View Single Post - long-awaited results! Phase II trial of AI+herceptin in advanced bc pts

Becky · 08-10-2006, 06:52 PM

Thanks for the post Lani.

It is very interesting that the combo of Herceptin and Femara has a response rate of 50% which is the response rate of each drug separately (when looking at data of Herceptin in the adjuvant setting and Femara in the adjuvant setting). I realize that advanced or metastatic disease is different and the use of an AI with Herceptin in the adjuvant setting could be a bigger one-two punch but I was hoping for better than 50% (that the combo would be better). However, if memory serves me well (and 50% of the time it doesn't - heehee), I think in the advanced/metastatic setting, an AI or Herceptin only has a 25% response rate (I think Herceptin 26%) so... if this is correct, the combo is much better.

Thanks again and kind regards

Becky

08-10-2006, 06:52 PM	#2
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Thanks for the post Lani. It is very interesting that the combo of Herceptin and Femara has a response rate of 50% which is the response rate of each drug separately (when looking at data of Herceptin in the adjuvant setting and Femara in the adjuvant setting). I realize that advanced or metastatic disease is different and the use of an AI with Herceptin in the adjuvant setting could be a bigger one-two punch but I was hoping for better than 50% (that the combo would be better). However, if memory serves me well (and 50% of the time it doesn't - heehee), I think in the advanced/metastatic setting, an AI or Herceptin only has a 25% response rate (I think Herceptin 26%) so... if this is correct, the combo is much better. Thanks again and kind regards Becky