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My mother is Her2 +1 and her pathology report says normal. We were done at the same lab and mine says Her2 +3 - overexpressed (so my mom's actually states Her 2 +1 - normal). I have always accepted that 0 or +1 is normal, +2 is borderline (and FISH should be done to confirm) and +3 is plain old overexpressed.
p53 (tumor suppressor gene) mutations are inherited and cause many different types of cancer including bc. Julierene on this board carries this mutation and may be able to help answer some of your friend's and your questions.
Kindest regards
Becky
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