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What about the wider issue of timing of TESTING.
I do not know anything about testing but how would the tests of two theoretical women with "identical" profiles tested at different times of the month appear.
Would their assessement of prognosis and treatment be different?
And what drives these cyclical changes and where do they originate. The point of the question would the point of origination alter views on the efficacy of ovarian removal - and considering possible higher impact of local production.
How does this change in the tumour oestrogen relate to change in other areas of the body.
Does the local production of eostrogen in the tumor cells and stromal bed etc follow the ovary or what ever is driving the oestrogen cycle.
OR are we looking at base level of production locally in tumour controlled by tumour plus effect of oestrogen cycle or shades inbetween or full linkage of all oestrogen to ovarian cycle.
Thanks for posting.
RB
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