HER2 Support Group Forums - View Single Post - Aromitase Inhibitors while on Chemo and ER/PR negative

Becky · 07-26-2006, 05:19 AM

Hope

There was a small study (I think only 12 women with metastatic bc - all were Her2+ but were initially ER/PR neg) that showed that 30% of these women changed to ER+. Moral of the story - retest pathology of mets if you can as the hormone receptor can change (especially in the presence of Herceptin).

We do know that the Her2 receptor can also change going from neg to positive as well. Cancer is a clever creature - Darwinism at its finest.

So, your onco may be just taking a chance that there has been a change. Its worth a shot.

Kind regards

Becky

07-26-2006, 05:19 AM	#3
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Hope There was a small study (I think only 12 women with metastatic bc - all were Her2+ but were initially ER/PR neg) that showed that 30% of these women changed to ER+. Moral of the story - retest pathology of mets if you can as the hormone receptor can change (especially in the presence of Herceptin). We do know that the Her2 receptor can also change going from neg to positive as well. Cancer is a clever creature - Darwinism at its finest. So, your onco may be just taking a chance that there has been a change. Its worth a shot. Kind regards Becky