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Jean · 07-20-2006, 04:16 PM

There is as yet no good drug to target the PTEN pathway. Velcade is not a good drug for this pathway as it really targets a protein degradeation pathway
mediated throught the endosome in the cell. There is a connection however it is tangential, between these pathways but it is far too tenuous to make a therapeutic decision. Moreover, the data are not at all clear that the PTEN alteration plays a direct role in HER2 positive tumors. There is no need for PTEN
testing at this point in time and it would not alter a treatment plan.

Hope this helps!
Jean

07-20-2006, 04:16 PM	#17
Jean Senior Member Join Date: Oct 2005 Location: New Jersey Posts: 3,154	Pten There is as yet no good drug to target the PTEN pathway. Velcade is not a good drug for this pathway as it really targets a protein degradeation pathway mediated throught the endosome in the cell. There is a connection however it is tangential, between these pathways but it is far too tenuous to make a therapeutic decision. Moreover, the data are not at all clear that the PTEN alteration plays a direct role in HER2 positive tumors. There is no need for PTEN testing at this point in time and it would not alter a treatment plan. Hope this helps! Jean