HER2 Support Group Forums - View Single Post

Lani · 07-19-2006, 10:41 PM

Ki67 is the best measure of proliferative rate. It is what is used in the OncoDx test as a marker of proliferation and it is what Drs Slamon and Pegram feel, in combination with ER, PR and her2 by FISH, best predict recurrence.

G=phase, S=phase, etc are a stage during cell division--I suppose they count how many cells they can see under the microscope are in that phase of division

Grade 2 is an obsolete term.I think I listed articles on this before. It probably means it is not as bad as Grade 3--but most have now been reclassified by other means (and some are Grade 3)

All agree that a low FISH score IS A GOOD THING. It is good that it is FISH positive, as herceptin felt to be effective primarily for FISH positive tumors and it also means that the gene is not as amplified (it is not copied as often so not as many receptors are on the surface of the cells sendiing signals which make the cells multiply like crazy)

Every patient has a unique tumor. Are you wondering where you fall in the bell-shaped curve of all breast cancer? OF her2 + breast cancer?

If it is really bothering you and if you are node negative, perhaps you should consider an OncoDx test.

There are no certain answers.

Hope this helped!

07-19-2006, 10:41 PM	#6
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	From what I have read Ki67 is the best measure of proliferative rate. It is what is used in the OncoDx test as a marker of proliferation and it is what Drs Slamon and Pegram feel, in combination with ER, PR and her2 by FISH, best predict recurrence. G=phase, S=phase, etc are a stage during cell division--I suppose they count how many cells they can see under the microscope are in that phase of division Grade 2 is an obsolete term.I think I listed articles on this before. It probably means it is not as bad as Grade 3--but most have now been reclassified by other means (and some are Grade 3) All agree that a low FISH score IS A GOOD THING. It is good that it is FISH positive, as herceptin felt to be effective primarily for FISH positive tumors and it also means that the gene is not as amplified (it is not copied as often so not as many receptors are on the surface of the cells sendiing signals which make the cells multiply like crazy) Every patient has a unique tumor. Are you wondering where you fall in the bell-shaped curve of all breast cancer? OF her2 + breast cancer? If it is really bothering you and if you are node negative, perhaps you should consider an OncoDx test. There are no certain answers. Hope this helped!