HER2 Support Group Forums - View Single Post - Doxil w/herceptin. Anyone on this combo or taken this combo?

cathy34 · 07-11-2006, 06:55 AM

I only had one round on Taxol when I started the A/C/T regimin about 2 year ago. I tolerated the first round of Taxol ok. Then came time for the 2nd round and my body just didn't like it! My heart started pounding (I felt like a cartoon character when they show the heart beating outside of the body) within 5-7 mins of the drug starting and my BP shot up to 190/140 and I couldn't breath (they had to give me oxygen) and I broke out in a red flush over my entire body. They immediately stopped the taxol and shot me full of benedryl and the reaction stopped. Of course this happened when my onc was on vacation. So, the covering onc said we'd try taxatere the following week. Well, that reaction was even worse! So, they have classified me as being extremely allergic to any drug in the taxane family. So, when my onc returned she said since we couldn't continue with the taxol that she would use what they used to use before taxol which was 2 more rounds on A/C along with 5FU. I think everyday being allergic to the taxol has really screwed me! However, as my Dr constantly tells me she's not going to kill me trying to cure me. I can buy that

I hope I can tolerate the doxil. They give it to you slow during the first round - 90 min drip, but with my track record she said she would do it over 2 hours.
I think during this journey, I found out that I am allregic to more meds than I ever thought.
I'm allergic to ... Zofran, Keflex, ALL cyclosporaines, penicillin, ALL taxanes, another anti-naseau drug that starts with an "A" (I have it written down).

Thanks for all your responses.

07-11-2006, 06:55 AM	#8
cathy34 Senior Member Join Date: Jan 2006 Posts: 30	Thanks for your responses...I'm allergic to ALL taxanes I only had one round on Taxol when I started the A/C/T regimin about 2 year ago. I tolerated the first round of Taxol ok. Then came time for the 2nd round and my body just didn't like it! My heart started pounding (I felt like a cartoon character when they show the heart beating outside of the body) within 5-7 mins of the drug starting and my BP shot up to 190/140 and I couldn't breath (they had to give me oxygen) and I broke out in a red flush over my entire body. They immediately stopped the taxol and shot me full of benedryl and the reaction stopped. Of course this happened when my onc was on vacation. So, the covering onc said we'd try taxatere the following week. Well, that reaction was even worse! So, they have classified me as being extremely allergic to any drug in the taxane family. So, when my onc returned she said since we couldn't continue with the taxol that she would use what they used to use before taxol which was 2 more rounds on A/C along with 5FU. I think everyday being allergic to the taxol has really screwed me! However, as my Dr constantly tells me she's not going to kill me trying to cure me. I can buy that I hope I can tolerate the doxil. They give it to you slow during the first round - 90 min drip, but with my track record she said she would do it over 2 hours. I think during this journey, I found out that I am allregic to more meds than I ever thought. I'm allergic to ... Zofran, Keflex, ALL cyclosporaines, penicillin, ALL taxanes, another anti-naseau drug that starts with an "A" (I have it written down). Thanks for all your responses. __________________ Only Positive Thoughts ++++++++++++++ -- Cathy34 Thanks to my wonderful husband Steve....I couldn't get through this without you! Wife and mother to 3 wonderful kids - ages 9, 8 and 3 Dx April 2004 Her2+++,ER/PR--,28lymph nodes removed - 2+, no rads Radical Mastectomy 5/2004 Recrunstruction 10/2004 Chemo .... A/C/T 5 FU Gemzar Avastin Xeloda Navelbine Herceptin Doxil Starting Tykerb Trial Lung Mets