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Lani · 07-07-2006, 04:28 PM

Are you ER or PR + You did not mention an AI, so I assume you are not. According to Drs. Spector and Bacus, who authored the article those who become resistant to Tykerb do so via the ER pathway, so if you are ER or PR +, you would have to be on Fulvestrant or an AI to help prevent that. If you are negative, you would not have to worry about that avenue of resistance.

As Becky said, Avastin remains available to you for the future anyway, since is FDA approved for other uses and can be used off-label.

I would hope they would reevaluate you with scans etc very frequently to allow you to switch to/add on Avastin quickly should the Tykerb not do the trick.

A paper was given at ASCO (or was it a poster) on what moledular tests on your original tumor would predict Tykerb efficacy--perhaps Becky or someone else who was at ASCO has the source--perhaps Targeted Molecular Diagnostics could test those markers. They usually give results in less than a week after a sample is received I think.

Good luck!

07-07-2006, 04:28 PM	#14
Lani Senior Member Join Date: Mar 2006 Posts: 4,780	Irene Are you ER or PR + You did not mention an AI, so I assume you are not. According to Drs. Spector and Bacus, who authored the article those who become resistant to Tykerb do so via the ER pathway, so if you are ER or PR +, you would have to be on Fulvestrant or an AI to help prevent that. If you are negative, you would not have to worry about that avenue of resistance. As Becky said, Avastin remains available to you for the future anyway, since is FDA approved for other uses and can be used off-label. I would hope they would reevaluate you with scans etc very frequently to allow you to switch to/add on Avastin quickly should the Tykerb not do the trick. A paper was given at ASCO (or was it a poster) on what moledular tests on your original tumor would predict Tykerb efficacy--perhaps Becky or someone else who was at ASCO has the source--perhaps Targeted Molecular Diagnostics could test those markers. They usually give results in less than a week after a sample is received I think. Good luck!