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The way it was explained to me by my Oncologist is that Herceptin itself doesn't increase or cause the chance of brain mets, it's that HER2+ women are living longer on Herceptin and therefore giving the Cancer more time to find the brain. I guess before Herceptin many of of HER2+ gals with mets would die before it had a chance to get into the brain. That's why I am waiting for them to OK the use of Tykerb along with HErceptin. Tykerb supposedly does enter the BBB...sherryg683
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