[R.B.]

****************** "Similarly, because aromatase is productive for a multifunctional physiological factor, estrogens, impaired metabolisms of bone, carbohydrate, and fat etc. result from the deficiency." *****************

I will look for links try and access full article but the above would suggest that intervention inthe aromatase pathways have the potential for a very wider range of side effects.

On the balance of probabilities we will see more long term effects with time.

I would reiterate my previous comments on fats.

RB














1: Nippon Rinsho. 2004 Feb;62(2):368-72. Related Articles, Links

[Aromatase deficiency]

[Article in Japanese]

Harada N.

Department of Biochemistry, Fujita Health University School of Medicine.

Aromatase, a key enzyme in estrogen synthesis, is tissue-specifically regulated in various tissues and plays an important role through endocrine and intracrine estrogen production in various physiological functions. Therefore, aromatase deficiency caused crucial impairments of physiological functions in the gonadal tissues as well as extra-gonadal tissues. Because aromatase is protective for androgenic exposure by catabolizing, virilization of a pregnant mother and pseudohermaphroditism of a baby girl consequently result from the deficiency. Similarly, because aromatase is productive for a multifunctional physiological factor, estrogens, impaired metabolisms of bone, carbohydrate, and fat etc. result from the deficiency. We discuss the etiology, clinical symptoms, and therapeusis by classifying it into two types of complete and incomplete aromatase deficiencies.

Publication Types:

* Review


PMID: 14968547 [PubMed - indexed for MEDLINE]