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CPA · 06-30-2006, 06:26 PM

The three week cycle was the standard protocol in both of the herceptin arms of the BCIRG 006 study presented at the SABCS in 2005.

This study was one of the primary sources used to justify adjuvant herceptin. I am assuming that most oncs will follow the same protocols used in the study because they were shown to work.

I am not aware if there are any studies comparing long term survival with 1 wk v. 3 wk herceptin cycles. Since the BCIRG study is not even through year 4, I doubt any studies comparing the two different administration timeframes are very mature.

The BCIRG study showed that using Herceptin with at least two combinations of chemo gave a better outcome than chemo alone in her2+ cancer patints. I am sure that over the next several years there will be multiple studies attempting to optimize the effectiveness of herceptin and other drugs by administering different combinations, dosages and frequencies.

06-30-2006, 06:26 PM	#2
CPA Senior Member Join Date: May 2006 Posts: 93	3 weeks The three week cycle was the standard protocol in both of the herceptin arms of the BCIRG 006 study presented at the SABCS in 2005. This study was one of the primary sources used to justify adjuvant herceptin. I am assuming that most oncs will follow the same protocols used in the study because they were shown to work. I am not aware if there are any studies comparing long term survival with 1 wk v. 3 wk herceptin cycles. Since the BCIRG study is not even through year 4, I doubt any studies comparing the two different administration timeframes are very mature. The BCIRG study showed that using Herceptin with at least two combinations of chemo gave a better outcome than chemo alone in her2+ cancer patints. I am sure that over the next several years there will be multiple studies attempting to optimize the effectiveness of herceptin and other drugs by administering different combinations, dosages and frequencies.