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al from Canada · 06-26-2006, 05:33 AM

From and interview with Dr. Clifford Husdis, May 23,2006:
"Now what about the patient who comes in with a preexisting cardiac issue and yet has a high-risk HER2-positive breast cancer? My sense right now is that without being able to do TOPO2 testing, you would err in the direction of giving the anthracycline. Another problem, which I think many medical oncologists don't always put to the forefront, is that if a patient has that degree of cardiac dysfunction, then the marginal benefit achieved with adjuvant therapy may not be so large anyway.

So the simple answer to your question is that right now there is no globally identifiable group of patients in whom the carboplatin-docetaxel regimen would be routinely appropriate. I do think that it is a good option for individual patients in specific circumstances."

He further goes on to say that if in doubt abot anthrcylines and herceptin, go with the Docetaxol / carbo / herceptin cobo. Everything I have read says DONOT GIVE CONCURRENT ANTHRACYCLINES AND HERCEPTIN! Can I say more? GET A SECOND OPINION!!
Good luck,
Ak

06-26-2006, 05:33 AM	#5
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	Topo2 From and interview with Dr. Clifford Husdis, May 23,2006: "Now what about the patient who comes in with a preexisting cardiac issue and yet has a high-risk HER2-positive breast cancer? My sense right now is that without being able to do TOPO2 testing, you would err in the direction of giving the anthracycline. Another problem, which I think many medical oncologists don't always put to the forefront, is that if a patient has that degree of cardiac dysfunction, then the marginal benefit achieved with adjuvant therapy may not be so large anyway. So the simple answer to your question is that right now there is no globally identifiable group of patients in whom the carboplatin-docetaxel regimen would be routinely appropriate. I do think that it is a good option for individual patients in specific circumstances." He further goes on to say that if in doubt abot anthrcylines and herceptin, go with the Docetaxol / carbo / herceptin cobo. Everything I have read says DONOT GIVE CONCURRENT ANTHRACYCLINES AND HERCEPTIN! Can I say more? GET A SECOND OPINION!! Good luck, Ak __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.