Hi tousled1, A big congratulations on getting through your first infusion of herceptin. Its always a relief to get through a new drug that you haven't had before.
Sounds like all was normal for you. Being tired is par for the course. Plus add the benadryl and that alone can make you extremly tired. But I have been on herceptin since Feb. of this year...weekly...and I can tell you for me...I am always the MOST tired the first day of I get the herceptin. In fact..its the one NIGHT I will actually sleep pretty good. After that, the rest of the week I wake up alot during the night? Don't know why?
But being on herceptin so far for me...is a piece of cake compared to all the other chemo drugs. The headache is quite normal. I know once they did not give me some tylenol BEFORE my herceptin. I stood up and WHAM...I had this terrible headache. But I always take the tylenol now before...and its never happened again. I think you will find it pretty easy after any other chemo drugs you have had.
I am glad it went well. 
Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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