I went looking for my saved material on the molecular wgts of a few chemos <sigh> I must have put it in a VERY safe place, as I can't find, ofcourse.
However, I did 'stumble' on this saved post:
Date: Mon Oct 25 2004 - 23:39:35 EDT
Just thought I would update all those who are interested in brain mets treatments on my sister J's status.
J has recurrent brain mets after WBR and several SRS treatments. Dr. Winer at Dana Farber wanted to put her on his new trial of GW572016 for brain mets, but felt Judi couldn't wait for the trial to open due to
her rapid progression. So he put her on Xeloda (2 weeks on 1 week off) for two cycles.(According to Dr.
Winer, Xeloda, with a molecular weight of 389 Daltons,
does in fact cross the blood brain barrier. Another Dr. at Dana Farber also informed me that Xeloda crosses the BBB--
Al, my search on the size shows up as 359, not 389. I think the reason for the trial using Xeloda in combination with the Tykerb is reasonable and most likely BECAUSE of the molecular wgt and 'anecdotal' good responses for brain mets. Me for example
)
Best to you,
pattyz