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al from Canada · 06-10-2006, 10:36 PM

although both Tykerb and herceptin are HER2 inhibitors, they work differently as one works on the intracellular domaine and the other on the extracellular domaine. That's why they are such a good fit together; sort of a belt and suspenders approach. The HER1 part of tykerb is the added bonus being small molecule and all. There is a trial for brain mets with Xeloda and Tykerb but, that; in my mind is questionable, as I think Xeloda is right on the molecular edge for blood / brain crossing. Lani, RB......is that right?

Al,

ps, I don't think I answered your question?????

06-10-2006, 10:36 PM	#9
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	action for Sandi although both Tykerb and herceptin are HER2 inhibitors, they work differently as one works on the intracellular domaine and the other on the extracellular domaine. That's why they are such a good fit together; sort of a belt and suspenders approach. The HER1 part of tykerb is the added bonus being small molecule and all. There is a trial for brain mets with Xeloda and Tykerb but, that; in my mind is questionable, as I think Xeloda is right on the molecular edge for blood / brain crossing. Lani, RB......is that right? Al, ps, I don't think I answered your question????? __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.