HER2 Support Group Forums - View Single Post - Oestrogen and hormones in breast cancer now and where they are made

R.B. · 05-31-2006, 03:57 AM

More thought provoking stuff to read.

RB

http://edrv.endojournals.org/cgi/content/full/26/3/322

Abstract

IN THE LAST DECADE or so, our knowledge of the roles of the steroids referred to as "sex hormones," namely testosterone and estradiol, has undergone a quiet revolution. In the first place, models of androgen and estrogen insufficiency, whether they be natural or engineered, have revealed new and unexpected roles for sex steroids, some of which have nothing to do with reproduction. Furthermore, both categories of steroid have roles in both sexes, which blunts the definition of the terms "androgen" and "estrogen." Secondly, the gradual acceptance of the role of local steroid hormone action, particularly as it applies in postmenopausal women and in men, provides new insights into the significance of paracrine and intracrine actions and requires a reevaluation of the importance of circulating steroid hormone levels.

05-31-2006, 03:57 AM	#2
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Estrogen—the Good, the Bad, and the Unexpected More thought provoking stuff to read. RB http://edrv.endojournals.org/cgi/content/full/26/3/322 Abstract IN THE LAST DECADE or so, our knowledge of the roles of the steroids referred to as "sex hormones," namely testosterone and estradiol, has undergone a quiet revolution. In the first place, models of androgen and estrogen insufficiency, whether they be natural or engineered, have revealed new and unexpected roles for sex steroids, some of which have nothing to do with reproduction. Furthermore, both categories of steroid have roles in both sexes, which blunts the definition of the terms "androgen" and "estrogen." Secondly, the gradual acceptance of the role of local steroid hormone action, particularly as it applies in postmenopausal women and in men, provides new insights into the significance of paracrine and intracrine actions and requires a reevaluation of the importance of circulating steroid hormone levels.