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Cef, Caf, Cmf
History Lesson:
Previous to the changeover to use of the taxanes as part of therapy several years ago, they used either CAF (in the US) or CEF (mostly in Europe, as there was some feeling that it was less cardiotoxic than CAF) for those who were HR+, and CMF for those who were HR-.
With the new information about topo II it appears that some HER2's may especially benefit from getting an anthracycline. The "A" in CAF is Adriamycin, or doxorubicin. The "E" in CEF is epirubicin. Both of these are anthracyclines. This is the same "A" that is used in the more recent regimens of AC followed by a taxane.
The "M" is not an anthracycline.
Hope that helps. CEF was used in this study but since there is no comparison with CAF or AC (the study only compared to CMF), regimens that contain either the E or the A assumably would do the trick in the same way.
AlaskaAngel
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