HER2 Support Group Forums - View Single Post - no evidence of increasd local recurrence or decreased survival assoc w needle biopsy

Lani · 05-19-2006, 11:04 PM

Al, her2 + breast cancer does seem to have a distinct way of behaving when stimulated by surgery compared to other cancers--I seem to remember reading it activated various thrombolytic (vs clotting) factors and particularly it is often associated with lots of VEGF. It's genetic profile is very similar to inflammation and wound healing and the recent article I posted recommended NOT having a mastectomy as it might stimulate these angiogenic, pro-metastasis and inflammatory factors. Nevertheless, they have never shown that having an oophorectomy is ill-advised in her2+ patients--in fact a paper by Love (Richard, not Susan) showed a marked survival advantage to doing a luteal phase oophorectomy and mastectomy in her2+ patients (small numbers, IHC 2+ and 3+ included)

Remember my post that Ki67 results do seem to depend on phase of menstrual cycle.
Al, I would appreciate a link to the 5FU recommendation.

I wanted to post this to stir up thinking about the fear generated by CLTann's posts months ago which might have caused a lot of fear in those who did have needle or core biopsies. Like so much, the answer is still not in...

05-19-2006, 11:04 PM	#12
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	"seeding " is an old concept probably outdated by new medical knowledge Al, her2 + breast cancer does seem to have a distinct way of behaving when stimulated by surgery compared to other cancers--I seem to remember reading it activated various thrombolytic (vs clotting) factors and particularly it is often associated with lots of VEGF. It's genetic profile is very similar to inflammation and wound healing and the recent article I posted recommended NOT having a mastectomy as it might stimulate these angiogenic, pro-metastasis and inflammatory factors. Nevertheless, they have never shown that having an oophorectomy is ill-advised in her2+ patients--in fact a paper by Love (Richard, not Susan) showed a marked survival advantage to doing a luteal phase oophorectomy and mastectomy in her2+ patients (small numbers, IHC 2+ and 3+ included) Remember my post that Ki67 results do seem to depend on phase of menstrual cycle. Al, I would appreciate a link to the 5FU recommendation. I wanted to post this to stir up thinking about the fear generated by CLTann's posts months ago which might have caused a lot of fear in those who did have needle or core biopsies. Like so much, the answer is still not in...