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Tom,
In the case of an 90 years old lady in my family starting on Herceptin alone, her oncologist stated that if she was to fail responding he would add Navelbine (low dose in view of the circumstances). He also said that DOXIL+Herceptin ( phase 2 clinical trial results recently published) would be an alternate combo though somewhat less gentle than Herceptin+Navelbine .
I also remember a study on a small group of patients showing signs of resistance who were readministered Herceptin: some responded again to the drug.
Finally you can look at what Gina did over the last 4 years: stopping 4 times treatment after a number of IV's when mets disappeared , then resuming IV's when visceral mets returned . She also adjusted the dosage of Herceptin according to the gravity of the mets. This is not exactly the situation of your mother but it shows Herceptin can be successfully readministered in some cases.
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