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heblaj01 · 05-18-2006, 09:07 AM

Thanks to all for replying to my initial post.
Since Herceptin is not shrinking primary tumours & for those who are unable or unwilling to tolerate chemo for that purpose, I am inclined to consider radiotherapy (especially if it can be combined with local hyperthermia as described in abstract below) as a way to downstage the primary tumour prior to surgical excision.

Has anyone undergone radiotherapy of primary tumours at the same time as getting Herceptin? or after?

17TH INTERNATIONAL CONGRESS ON ANTI-CANCER TREATMENT (jan-feb06)

http://www.icact.com/Abstract_Book_ICACT_2006.pdf (p.181)

■ POSTER SESSION

Effect of Local Hyperthermia combinedwith External Radiation Therapy as AntiCancer-treatment in Recurrent Breast Cancer
Rigler Marcus Yves, Spenger M, Lenhart U.med-uni-graz - Graz - Austria

Hyperthermia combined with radiation therapy has been confirmed in several randomised studies to be more effective than radiation therapy alone in various cancers. We evaluated the potential synergistic effect of local hyperthermia and conventional external beam radiation.

We used a wave-guide applicator with a typical emitting diameter of 15 cm and a frequency of 150-430 MHz with a therapeutic depth of 3 cm. Hyperthermia was performed for 60 minutes for at total of six sessions, twice weekly, the temperature was exactly calibrated between 40and 43 degrees C. Immediately after hyperthermia external radiation with 60 Gy was applied in a daily fraction of 1.5 Gy. No major side effects were observed during hyperthermia.

Twelve patients were treated and followed for during 2-12months. Ten of the tumours responded to the treatment (3 CR, 7PR), two patients died of distant metastases within one year.Local hyperthermia combined with conventional radiation therapy may be useful tool to promote tumor regression and the local recurrence-free survival in cases of recurrance breast cancer.We conclude that hyperthermia and radiation therapy is effective in treatment breast cancer treatment and should be used in selected cancer patients

05-18-2006, 09:07 AM	#5
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Thanks to all for replying to my initial post. Since Herceptin is not shrinking primary tumours & for those who are unable or unwilling to tolerate chemo for that purpose, I am inclined to consider radiotherapy (especially if it can be combined with local hyperthermia as described in abstract below) as a way to downstage the primary tumour prior to surgical excision. Has anyone undergone radiotherapy of primary tumours at the same time as getting Herceptin? or after? 17TH INTERNATIONAL CONGRESS ON ANTI-CANCER TREATMENT (jan-feb06) http://www.icact.com/Abstract_Book_ICACT_2006.pdf (p.181) ■ POSTER SESSION *Effect of Local Hyperthermia combinedwith External Radiation Therapy as AntiCancer-treatment in Recurrent Breast Cancer* Rigler Marcus Yves, Spenger M, Lenhart U.med-uni-graz - Graz - Austria Hyperthermia combined with radiation therapy has been confirmed in several randomised studies to be more effective than radiation therapy alone in various cancers. We evaluated the potential synergistic effect of local hyperthermia and conventional external beam radiation. We used a wave-guide applicator with a typical emitting diameter of 15 cm and a frequency of 150-430 MHz with a therapeutic depth of 3 cm. Hyperthermia was performed for 60 minutes for at total of six sessions, twice weekly, the temperature was exactly calibrated between 40and 43 degrees C. Immediately after hyperthermia external radiation with 60 Gy was applied in a daily fraction of 1.5 Gy. No major side effects were observed during hyperthermia. Twelve patients were treated and followed for during 2-12months. Ten of the tumours responded to the treatment (3 CR, 7PR), two patients died of distant metastases within one year.Local hyperthermia combined with conventional radiation therapy may be useful tool to promote tumor regression and the local recurrence-free survival in cases of recurrance breast cancer.We conclude that hyperthermia and radiation therapy is effective in treatment breast cancer treatment and should be used in selected cancer patients