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When I took Tamoxifen (I am now on Arimidex), I took 20mg once a day. I had some hot flashes and I also had some minor vision problems (which is a side effect) but it did not inhibit me.
I did get uterine thickening. Since ovarian cancer also runs in my family and I am PR neg (but ER pos) and AIs work better with this pathology (and I am 46 and done with children), I had my ovaries removed in order to take an AI.
The eye and uterine problems disappeared (but not the hot flashes which were minimal with both).
Regards
Becky
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