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heblaj01 · 05-15-2006, 03:42 PM

I have no direct experience with the combo Herceptin/Femara/Zometa you are treated with.
But from experience with Femara & Zometa & the available data on Herceptin I would say this should be a successful treatment.
Femara is the stronghest estrogen suppressor among the aromatase inhibitor drugs. It may take 3 to 6 months to show maximum results on markers.
Because of the deep estrogen supression Zometa is used to prevent damage to bones sometimes severe in patients prone to osteoporosis.
I would not rely only a yearly Bone Density scan to find (sometimes too late) that bone loss is so extensive that compression fractures, scoliosis are likely.
There are several bone resorption markers (such as urine or serum NTx & CTx tests) which can show the trend in bone condition every 6 to 8 weeks if that frequeny is required. (The Bone Density scan needs longer time intervals to show changes). Zometa can start decreasing the level of the resorption markers after one or two monthly infusions. So its efficacy can be quicly cheked .
Zometa, if infused on a monthly basis, may result in an other benefit: antiangionesis. Experiments on a small group of patients has demonstrated that a single shot of Zometa reduces by 34% the VEGF cancer growth factor measured 21 days after the infusion.
On a personal note I have observed in a elderly lady in my family that a 3 months treatment with Zometa alone (for osteoporosis) brought down CEA to the same low level achieved by Femara long after the latter was discontinued.
I cannot say it always happens this way but I hope it will in your case.
Long term trials (called ZO-FAST) are underway combining Femara & twice yealy Zometa.Interim reports have been published.
To put all chances of success on your side & reduce the risk of some of the pitfalls related to Zometa I would extend the infusion time to 30 minutes from the standard 15 (may help protect your kidneys & keep your creatinine marker steady).
Supplementing with CoQ10 may also help keep kidneys healthy although I have no clinical trial results to prove it in the case of Zometa induced kidney damage. But in other situations of kidney damage it has demonstrated beneficial effects.
However I would recommand you check with your onc before trying CoQ10.
Avoid any dental work &/or damage to gums while on Zometa to reduce the already low risk of serious avascular maxillary necrosis.

05-15-2006, 03:42 PM	#3
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	does any one have advice/encouragement?? I have no direct experience with the combo Herceptin/Femara/Zometa you are treated with. But from experience with Femara & Zometa & the available data on Herceptin I would say this should be a successful treatment. Femara is the stronghest estrogen suppressor among the aromatase inhibitor drugs. It may take 3 to 6 months to show maximum results on markers. Because of the deep estrogen supression Zometa is used to prevent damage to bones sometimes severe in patients prone to osteoporosis. I would not rely only a yearly Bone Density scan to find (sometimes too late) that bone loss is so extensive that compression fractures, scoliosis are likely. There are several bone resorption markers (such as urine or serum NTx & CTx tests) which can show the trend in bone condition every 6 to 8 weeks if that frequeny is required. (The Bone Density scan needs longer time intervals to show changes). Zometa can start decreasing the level of the resorption markers after one or two monthly infusions. So its efficacy can be quicly cheked . Zometa, if infused on a monthly basis, may result in an other benefit: antiangionesis. Experiments on a small group of patients has demonstrated that a single shot of Zometa reduces by 34% the VEGF cancer growth factor measured 21 days after the infusion. On a personal note I have observed in a elderly lady in my family that a 3 months treatment with Zometa alone (for osteoporosis) brought down CEA to the same low level achieved by Femara long after the latter was discontinued. I cannot say it always happens this way but I hope it will in your case. Long term trials (called ZO-FAST) are underway combining Femara & twice yealy Zometa.Interim reports have been published. To put all chances of success on your side & reduce the risk of some of the pitfalls related to Zometa I would extend the infusion time to 30 minutes from the standard 15 (may help protect your kidneys & keep your creatinine marker steady). Supplementing with CoQ10 may also help keep kidneys healthy although I have no clinical trial results to prove it in the case of Zometa induced kidney damage. But in other situations of kidney damage it has demonstrated beneficial effects. However I would recommand you check with your onc before trying CoQ10. Avoid any dental work &/or damage to gums while on Zometa to reduce the already low risk of serious avascular maxillary necrosis.