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Christine
There was also a trial by Lupu and Menendez revealing a bidirectional connection between HER2 and FAS.
I have seen another trial linking Her2 and FAS.
I have also from memory (I cant find it at the moment) seen suggestions HER 2 is down mediated by Omega three. (There are several general BC studies suggestion down mediation by n3 and Derivatives DHA etc)
Her overexpression stimulates Fas promoter and mediates endogenous fatty synthesys.
Fas blockade sensitises to Herceptin.
Hence my questions as to whether Herceptin mediates Fas and thereby reduces long chain synthesis - my concern is DHA production with the potential impact that would have in diets which are already deficient.
If Herceptin were to work in part by stopping AA production, and AA is in part a factor in BC - what would be the impact of regional production in the brain of AA etc if herceptin does not cross into the brain?
From my reading I still would on the odds rank omega three above nine in criticality in the process.
Much to think about.
RB
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