HER2 Support Group Forums - View Single Post - and here it is...lapatinib resistance due to ER signalling

al from Canada · 05-11-2006, 02:28 PM

This is a great post Lani,
It only makes sense.... one way to resensitize ER inhibitor resistant BC cells is to give a HER1 inhibitor so it makes sense to give a ER inhibitor for HER type drug resistance. Slamon said some of his best results are with cuncerrent faslodex and herceptin. Lapatinib + an aromitase inhibitor....I sure wish that was available 6 months ago!

Al

05-11-2006, 02:28 PM	#3
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	This is a great post Lani, It only makes sense.... one way to resensitize ER inhibitor resistant BC cells is to give a HER1 inhibitor so it makes sense to give a ER inhibitor for HER type drug resistance. Slamon said some of his best results are with cuncerrent faslodex and herceptin. Lapatinib + an aromitase inhibitor....I sure wish that was available 6 months ago! Al __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.