Hi Christine;
I'm one who has progressed while on Herceptin, and my onc's method has been to add a single agent chemo for 6 months until I'm in remission or considered stable enough to maintain on Herceptin until I need a chemo again. For me, this has been very effective. The chemo's we've used so far have been Navelbine (for 3 recurrences) and Xeloda added to this last round of Navelbine/Herceptin. In fact, I just saw my onc today and we decided to drop the Navelbine as I've responded so well, and maintain on Xeloda/Herceptin for awhile.
If you search the message board using "herceptin progression" you'll find quite a few posts on this subject, but in case you have difficulty doing that here's a link(hopefully) to the search I did:
Message Board "herceptin progression"
http://her2support.org/vbulletin/sea...searchid=17889
<3 Lolly
PS. Sorry if the link didn't work when I first posted it, I think it's fixed now.