HER2 Support Group Forums - View Single Post - Docetaxel, cisplatin, and trastuzumab show great result

jhandley · 05-04-2006, 11:45 PM

If you read "the her 2 story" you will see that Dennis Slamon wanted to do the phase 3 trials with a platinum drug because the phase 1 and 2 trials were done with cisplatin (I think from memory) and also lab tests had shown profound synergy with herceptin. Anyway he was overruled by the drug company who according to the book were a bit nervous about using a drug that wasn't active on its own against breast cancer. Apparently that is why they went with taxol. It has since been shown that the median time to progression in a phase 3 trial of herceptin/taxol/carboplatin versus just herceptin/taxol was more than doubled in a study of Stage IV patients.
I tried to get carboplatin added to my regime in Oct last year when these trial results came out but wasnt able to.
Jackie

05-04-2006, 11:45 PM	#7
jhandley Senior Member Join Date: Sep 2005 Location: Melbourne Victoria Australia Posts: 330	platinum drugs If you read "the her 2 story" you will see that Dennis Slamon wanted to do the phase 3 trials with a platinum drug because the phase 1 and 2 trials were done with cisplatin (I think from memory) and also lab tests had shown profound synergy with herceptin. Anyway he was overruled by the drug company who according to the book were a bit nervous about using a drug that wasn't active on its own against breast cancer. Apparently that is why they went with taxol. It has since been shown that the median time to progression in a phase 3 trial of herceptin/taxol/carboplatin versus just herceptin/taxol was more than doubled in a study of Stage IV patients. I tried to get carboplatin added to my regime in Oct last year when these trial results came out but wasnt able to. Jackie