HER2 Support Group Forums - View Single Post - tamoxifen's anorectic effect via alteration of fatty acid synthetase in hypothalamus-

R.B. · 04-29-2006, 10:37 AM

Thanks Lani.

I wondered if and how tamoxifen impacted on FAS.

I noted that they used it as part of an experiment to create PPAR (alpha?) null mice, and wondered what it was about tamoxifen that influenced PPAR activity.

Does this include inhibition of production of omega six series two derivatives COX 2 though reduction of AA production, as well as what ever else it does.

Many thanks

RB

04-29-2006, 10:37 AM	#2
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Thanks Lani. I wondered if and how tamoxifen impacted on FAS. I noted that they used it as part of an experiment to create PPAR (alpha?) null mice, and wondered what it was about tamoxifen that influenced PPAR activity. Does this include inhibition of production of omega six series two derivatives COX 2 though reduction of AA production, as well as what ever else it does. Many thanks RB