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snoopy · 04-11-2006, 11:41 AM

Hi Tom

The elimination half life of Herceptin is long (the time it takes for levels of drug in blood to decrease by 50%)

The following is from the UK summary of product characteristics for the product (on www.emc.medicines.org.uk)

"Using the recommended dose, the half-life is approximately 28.5 days (95 % confidence interval, 25.5 –32.8 days). The washout period is up to 24 weeks (95 % confidence interval, 18-24 weeks)"

I was told that the HERA protocol actually allowed the interval between doses to be as long as 4 weeks (rather than the scheduled 3) before "reloading " with herceptin was required.

So an odd day different in administration schedule wouldn't seem to be a problem.

04-11-2006, 11:41 AM	#9
snoopy Senior Member Join Date: Oct 2005 Posts: 35	Herceptin schedules Hi Tom The elimination half life of Herceptin is long (the time it takes for levels of drug in blood to decrease by 50%) The following is from the UK summary of product characteristics for the product (on www.emc.medicines.org.uk) "Using the recommended dose, the half-life is approximately 28.5 days (95 % confidence interval, 25.5 –32.8 days). The washout period is up to 24 weeks (95 % confidence interval, 18-24 weeks)" I was told that the HERA protocol actually allowed the interval between doses to be as long as 4 weeks (rather than the scheduled 3) before "reloading " with herceptin was required. So an odd day different in administration schedule wouldn't seem to be a problem.