HER2 Support Group Forums - View Single Post - low weight(or BMI) is a risk factor for her2+ breast cancer

03-28-2006, 01:23 PM

Breast cancer is very very complex.

The working of the body are very complex.

Estrogen expression links into may of the bodies activities and systems including fat in take and particularly fat type and balance. Estrogen links with fatty acid making and utilisation systems, with insulin, leptin, weight control.........

My question after much reading is what is really in the driving seat in all of this. Estrogen is in there but is it the foot on the pedal, the cable, the injection system, the valves or the pistons (except in BC there are many more bits thousand probably all interlinking). Whose driving? My personal very amatuer guess is omega six being out of balance with omega three primarily is the foot on the pedal - are there links to oestrogen - yes, and lots of other factors beside. You can be fat or thin and have an omega three six imbalance. Those on low fat high polyunsaturates (veg oils margerine etc) superfit low weighters BY VIRTUE OF THEIR CONSUMPTION OF HIGH SIX SOURCES (VEG OILS) COMBINED WITH FAT AVOIDANCE (other very low level omega three sources at high volume eaten by heavier people) ARE ACTUALY MORE LIKELY TO HAVE A HIGH OMEGA 3 / 6 IMBALANCE, and hence a possible apparent link between lower body weight and HER2 I suggest.

CAN FATS HAVE SO MUCH IMPACT IN THE BODY - YES THEY CAN!! They have a huge range of functions act as hormones, controllers of all sorts of functions - FATS ARE HEAP POWERFUL.

Many of the functions fats insulin leptin estrogen................ are multiply related to each other and talk directly and indirectly to each other.

At a common sense level this suggests the need for a multiple approach combining chosen treatments with dietary improvements etc.

My overall perspective is even if the omega three six balance is not the driver (and somthing has to be - this growth in BC has not appeared out of nothing and nowhere, someting has changed) all balancing the omegas threes and sixes will do is generally is improve your health. ( Always check with advisers before considering significant dietary changes.)

RB

03-28-2006, 01:23 PM	#4
Unregistered Guest Posts: n/a	Breast cancer is very very complex. The working of the body are very complex. Estrogen expression links into may of the bodies activities and systems including fat in take and particularly fat type and balance. Estrogen links with fatty acid making and utilisation systems, with insulin, leptin, weight control......... My question after much reading is what is really in the driving seat in all of this. Estrogen is in there but is it the foot on the pedal, the cable, the injection system, the valves or the pistons (except in BC there are many more bits thousand probably all interlinking). Whose driving? My personal very amatuer guess is omega six being out of balance with omega three primarily is the foot on the pedal - are there links to oestrogen - yes, and lots of other factors beside. You can be fat or thin and have an omega three six imbalance. Those on low fat high polyunsaturates (veg oils margerine etc) superfit low weighters BY VIRTUE OF THEIR CONSUMPTION OF HIGH SIX SOURCES (VEG OILS) COMBINED WITH FAT AVOIDANCE (other very low level omega three sources at high volume eaten by heavier people) ARE ACTUALY MORE LIKELY TO HAVE A HIGH OMEGA 3 / 6 IMBALANCE, and hence a possible apparent link between lower body weight and HER2 I suggest. CAN FATS HAVE SO MUCH IMPACT IN THE BODY - YES THEY CAN!! They have a huge range of functions act as hormones, controllers of all sorts of functions - FATS ARE HEAP POWERFUL. Many of the functions fats insulin leptin estrogen................ are multiply related to each other and talk directly and indirectly to each other. At a common sense level this suggests the need for a multiple approach combining chosen treatments with dietary improvements etc. My overall perspective is even if the omega three six balance is not the driver (and somthing has to be - this growth in BC has not appeared out of nothing and nowhere, someting has changed) all balancing the omegas threes and sixes will do is generally is improve your health. ( Always check with advisers before considering significant dietary changes.) RB