HER2 Support Group Forums - View Single Post - Attempting to increase rate of Herceptin efficacy,decrease rate of Hercptn resistance

03-27-2006, 10:53 AM

Hi Julierene,

I too agree that genetics often underplayed when it comes to reasons why one develops breast cancer. We are told that most bcs are spontaneous and not as a result of genetics. However, I really wonder if many of us who develop bc do so as a result of lack of certain oncogenes that prevent oncogenesis. See the following link for more on oncogenes for her2.

http://carcin.oxfordjournals.org/cgi.../26/3/643?etoc

PS. For many of us who get bc, I speculate that a host of events coupled with genetics causes bc with often estrogen and estrogen like compounds stimulating the ominous cancer cell transformation to begin with. Obviously, estrogen is a central culprit; else more males would develop bc.

03-27-2006, 10:53 AM	#43
Unregistered Guest Posts: n/a	Hi Julierene, I too agree that genetics often underplayed when it comes to reasons why one develops breast cancer. We are told that most bcs are spontaneous and not as a result of genetics. However, I really wonder if many of us who develop bc do so as a result of lack of certain oncogenes that prevent oncogenesis. See the following link for more on oncogenes for her2. http://carcin.oxfordjournals.org/cgi.../26/3/643?etoc PS. For many of us who get bc, I speculate that a host of events coupled with genetics causes bc with often estrogen and estrogen like compounds stimulating the ominous cancer cell transformation to begin with. Obviously, estrogen is a central culprit; else more males would develop bc.