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al from Canada · 02-16-2006, 05:53 PM

My apologies ladies for unwittingly complicating this for many of you. I think the intent of my post(s) was to bring an awareness that as our treatments may become more complex (and targetted) and so will the molecular profiling. When I think back on one of the very first discussions on this board about this very topic, it was about oleaic acid (omega 9's in olive oil) and synergy with herceptin.

What we've learned since then is that blocking one pathway (say HER2) is a short fix (for most) and blocking more that one pathway (such as EGFR or VGEF or ER with iressa or avastin or arimidex respectively) may lead to a more sustained response.

As far as being prositive or negative...the jury is still out. For example, HER2 positive has turned into what no one would have predicted.... a blessing in disguise. Only time will tell about the rest.

As always,
Al

02-16-2006, 05:53 PM	#10
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	soory about confusion My apologies ladies for unwittingly complicating this for many of you. I think the intent of my post(s) was to bring an awareness that as our treatments may become more complex (and targetted) and so will the molecular profiling. When I think back on one of the very first discussions on this board about this very topic, it was about oleaic acid (omega 9's in olive oil) and synergy with herceptin. What we've learned since then is that blocking one pathway (say HER2) is a short fix (for most) and blocking more that one pathway (such as EGFR or VGEF or ER with iressa or avastin or arimidex respectively) may lead to a more sustained response. As far as being prositive or negative...the jury is still out. For example, HER2 positive has turned into what no one would have predicted.... a blessing in disguise. Only time will tell about the rest. As always, Al __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.