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PTEN is a biomarker like Her2 is. In trials they think that you need PTEN to be present for Herceptin to respond. But, if you dont have it, they are just in trials to get PTEN inhibitors. This might be years down the road. EGFR is a biomarker too. They found if Her2 is stopped then the cancer might find it's way through the EGFR pathway if you have that present. EGFR inhibitors are like Lapatinib which is in trials right now. Michele u
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