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I am also on my off week from my second round of Xeloda...i hate it. I hate taking pills everyday, I am on 3000mg. It's suppose to be a great drug though. My main issue is the hand/foot thing. My hands will be great for 3 days or so then all of a sudden from no where I wake up with them feeling like I placed them on a stove top. I have been off Xeloda now since Friday and I woke up this morning with hand and feet killing me. There seems to be no consistancy in when I get this H/F thing. I love playing tennis and can't seem to do it because it aggrivates my hand and feet. I have had a little diahrrea but that's pretty normal for me...no vomiting. It does seem to zap my energy though about an hour after I take them....sherryg683
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