I found an interesting applicable link concerning late Herceptin featuring Dr. Love , Fox and Winer. I will post this link below. Basically, they discuss the idea of late Herceptin. Looks like they state that 33% relapse in the first few years. Supposedly they base their decision for no herceptin based on that fact. However, a 66% relapse rate remains which could be significant not only in the short 10 year survival stats but the longer 20 year stats.
http://www.meettheprofessors.com/mtp/2005/6/default.htm
try the below link for the direct case, otherwise use the above link and look at case 1
http://www.meettheprofessors.com/mtp/2005/6/case1.htm
According to Dr. Miller of Breastcancer.org, ER-negative have a higher rate of recurrences in the first FIVE YEARS after diagnosis, but the long-term prognosis is comparable with ER-positive tumors.
According to "Adjuvant Systmeic Therapy for Lymph Node negative Breast Cacner less than or Equal to 1cm," 66% of bc relapse is in the first 10 years and 33% in years 11-20.