[Ginagce]

I finally contacted Genentech regarding the pain side effects & Herceptin.

Although they said there was data to answer my questions....

They could not give me the answers to my questions as they said my questions all involved "off label" use. I am not stage IV which is why it's still off label, pending FDA approval. But they did tell me they could give data to my oncologist. So I am now waiting to hear back from my oncologist after she calls them.

Basically my questions were:

Original trials with 7% patients reporting bone/joint/muscle pain were done on weekly dosing schedule only.

What is the data from newer trials with non stage IV patients receiving herceptin every three weeks in denser doses.

What is the data from newer trials of patients receiving herceptin on a three weekly dosing who are also taking AI's. Is one perhaps better than the other in combination with the herceptin.

I will let you all know what I find out.

Blessings to all!

Ginagce