As usual the more I read the more complex it all gets.
I dont pretend to understand much of this, I just get occasional hints of a maybe outline in the mist.
This abstract relates Cox 2 arachidonic acid which are both involved in the omega six eicosanoid pathway, PPAR gamma, and fat storage metabolism which in a sense is a key function of the breast.
It also links in insulin.
My point is that the make up of fat intake potentially has the ability to influence the bodies operation at a very fundamental level, and in areas that are reported to be relevant to breast cancer.
I am afraid you will have to draw your own inferences - this is strictly amateur interest.
RB
http://mend.endojournals.org/cgi/con...ull/16/11/2628
ABSTRACT
THE PEROXISOME PROLIFERATOR-activated receptors (PPARs, NR1C1, NR1C2, NR1C3; Ref. 1) are members of the nuclear receptor superfamily. They function as heterodimers with the receptor of 9-cis-retinoic acid (RXR, NR2B; Ref. 1), and bind to specific peroxisome proliferator response elements (PPREs) to regulate transcription of their target genes. Three different PPAR genes have been characterized, which give rise to four distinct proteins ({alpha}, ß/{delta}, {gamma}1, and {gamma}2). Although the PPARs were first cloned as orphan members of the nuclear receptor gene family, rapid progress has been made in their functional analysis. This research contributed to a better understanding of the importance of fatty acids as hormones and has established the PPARs as molecular targets for the development of drugs to treat human diseases (2).
PPAR{gamma} is expressed predominantly in adipose tissue, where it is known to play a critical role in adipocyte differentiation and fat deposition (3, 4). It can be activated by arachidonic acid-metabolites generated by the cyclooxygenase and lipooxygenase pathways (5, 6, 7) and by fatty acid-derived components released from oxidized low density lipoproteins (8). The antidiabetic thiazolidinediones (TZDs), currently used as insulin sensitizers, are the best synthetic PPAR{gamma} ligands in terms of specificity and affinity, although the mechanism by which activation of PPAR{gamma} leads to an improvement of insulin action is still debated (3, 4, 9). Moreover, deletion of one allele of PPAR{gamma} was recently shown to protect mice from high fat diet (HFD)-induced adipocyte hypertrophy and insulin resistance, underlying the complexity of the role of PPAR{gamma} in insulin sensitivity (10).
The most extensively studied therapeutic utility for PPAR{gamma} has been in the treatment of type 2 diabetes. ......