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If a person is HER2+++ and responds to Herceptin, they have a good chance of doing better with overall survival than otherwise. Responding to Herceptin can control spread to organs etc, leaving a person with good Karnofsky score. Herceptin alone has nothing to do with brain mets according to current medical reports. That is my understanding.
The bottom line in "long term" survival with brain mets seems to be controlled mets otherwise. I've lost too many dear friends whose mets progressed in other areas, who did have controlled or near controlled brain mets.
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