HER2 Support Group Forums - View Single Post - prognosis for early stage node negative her2 defined:

RobinP · 02-09-2006, 11:52 AM

Interesting Lani. However, most of us that are her2+ are er,pr, negative, not postivie as the patients in this study. Not surprisingly, you would expect to see up regulation of her2 in er,pr+ cancer when estrogen is deprived as the cancer seeks another pathway of growth as opposed to the estrogen pathway.However, this is not to say that declining estrogen levels is the CAUSE of her2 bc. No if this be the case then all er,pr+ bc that is her2- would convert to her2+ when an antiestogen would be given and we know this does not happen.

02-09-2006, 11:52 AM	#14
RobinP Senior Member Join Date: Nov 2005 Posts: 943	Interesting Lani. However, most of us that are her2+ are er,pr, negative, not postivie as the patients in this study. Not surprisingly, you would expect to see up regulation of her2 in er,pr+ cancer when estrogen is deprived as the cancer seeks another pathway of growth as opposed to the estrogen pathway.However, this is not to say that declining estrogen levels is the CAUSE of her2 bc. No if this be the case then all er,pr+ bc that is her2- would convert to her2+ when an antiestogen would be given and we know this does not happen. __________________ Robin 2002- dx her2 positive DCIS/bc TX Mast, herceptin chemo Last edited by RobinP; 02-09-2006 at 11:55 AM..