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al from Canada · 02-08-2006, 11:16 PM

JoJo and Kim,

Apart from the drug, (Tremodar) that Joe mentioned, only "small molecule" inhibitors cross the BBB. The two that are approved (for other cancers) that do cross the BBB are Iressa and Tarceva and then lapatinib; which isn't approved for anything yet. There are others that target multiple pathways that I am less familiar with such as Nexavar® (sorafenib) and Sutent® (sunitinib), and pertuzumab, and Avastin which targets VEGF. I don't know if any of those cross the BBB and in terms of Avastin, I don't think the researchers know either. Pertuzumab is a monoclonal antibody therefore it is a large molecule drug and willmot cross the BBB.
Linda just completed the RSR3 trial with WBR and I guess time will tell how well it works.

I hope this has helped,
Al

02-08-2006, 11:16 PM	#5
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	JoJo and Kim, Apart from the drug, (Tremodar) that Joe mentioned, only "small molecule" inhibitors cross the BBB. The two that are approved (for other cancers) that do cross the BBB are Iressa and Tarceva and then lapatinib; which isn't approved for anything yet. There are others that target multiple pathways that I am less familiar with such as Nexavar® (sorafenib) and Sutent® (sunitinib), and pertuzumab, and Avastin which targets VEGF. I don't know if any of those cross the BBB and in terms of Avastin, I don't think the researchers know either. Pertuzumab is a monoclonal antibody therefore it is a large molecule drug and willmot cross the BBB. Linda just completed the RSR3 trial with WBR and I guess time will tell how well it works. I hope this has helped, Al __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.