HER2 Support Group Forums - View Single Post - Increasing Serum HER2 Test Results

02-08-2006, 09:02 AM

unfortunately it included only 86 patients both her2neu positive and negative, so probably only 20 or so were her2 positive to start with. I have not seen the whole article yet, so will have to check out if they used the Bayer/Oncogene technology as they do at LabCorp

1: J Clin Pathol. 2006 Feb 3; [Epub ahead of print] Related Articles, Links

Serum HER-2 concentration in patients with primary breast cancer.

Kong SY, Kang JH, Kwon Y, Kang HS, Chung KW, Kang SH, Lee DH, Ro J, Lee ES.

National Cancer Center, Korea, Republic of.

AIMS: To evaluate whether serum HER-2/neu (HER-2) concentration is a valid index of HER-2 status in women with primary breast cancer and to establish a normal reference range for serum HER-2 concentration in Korean women. METHODS: We measured serum HER-2 concentration and performed immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) on tissue samples from 86 consecutive female patients, and we compared the results of the 3 data sets. We determined the cutoff value of HER- 2 concentration from the mean + 2 SD of values derived from the serum of 93 healthy volunteers. RESULTS: The IHC and FISH data were significantly associated with each other (P < 0.01), but neither showed significant concordance with the serum HER- 2 data. The cutoff value of serum HER-2 was 10.2 g/L, and the serum HER-2 concentration of patients with primary breast cancer ranged from 5.0 to 17.5 g/L. Only 5 patients showed a serum HER-2 value above the cutoff value. CONCLUSIONS: Serum HER-2 concentration cannot be substituted for IHC or FISH to evaluate HER-2 status, nor can it be used as a diagnostic tumor marker in primary breast cancer considering the low prevalence of serum HER- 2 elevation.

PMID: 16461567 [PubMed - as supplied by publisher]

02-08-2006, 09:02 AM	#5
Lani Guest Posts: n/a	thanks for the citation--fresh off the press a NEW article on serum her2neu unfortunately it included only 86 patients both her2neu positive and negative, so probably only 20 or so were her2 positive to start with. I have not seen the whole article yet, so will have to check out if they used the Bayer/Oncogene technology as they do at LabCorp 1: J Clin Pathol. 2006 Feb 3; [Epub ahead of print] Related Articles, Links Serum HER-2 concentration in patients with primary breast cancer. Kong SY, Kang JH, Kwon Y, Kang HS, Chung KW, Kang SH, Lee DH, Ro J, Lee ES. National Cancer Center, Korea, Republic of. AIMS: To evaluate whether serum HER-2/neu (HER-2) concentration is a valid index of HER-2 status in women with primary breast cancer and to establish a normal reference range for serum HER-2 concentration in Korean women. METHODS: We measured serum HER-2 concentration and performed immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) on tissue samples from 86 consecutive female patients, and we compared the results of the 3 data sets. We determined the cutoff value of HER- 2 concentration from the mean + 2 SD of values derived from the serum of 93 healthy volunteers. RESULTS: The IHC and FISH data were significantly associated with each other (P < 0.01), but neither showed significant concordance with the serum HER- 2 data. The cutoff value of serum HER-2 was 10.2 g/L, and the serum HER-2 concentration of patients with primary breast cancer ranged from 5.0 to 17.5 g/L. Only 5 patients showed a serum HER-2 value above the cutoff value. CONCLUSIONS: Serum HER-2 concentration cannot be substituted for IHC or FISH to evaluate HER-2 status, nor can it be used as a diagnostic tumor marker in primary breast cancer considering the low prevalence of serum HER- 2 elevation. PMID: 16461567 [PubMed - as supplied by publisher]