Lani

and somatostatin analog octreotide--now I am totally confused:


: Regul Pept. 2005 Dec 19; [Epub ahead of print] Related Articles, Links

Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori.

Kao JY, Pierzchala A, Rathinavelu S, Zavros Y, Tessier A, Merchant JL.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, 6520A MSRB 1, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0650, USA.

Somatostatin is a regulatory peptide found in abundance in the stomach. We have previously shown that somatostatin is required for IL-4-mediated resolution of Helicobacter pylori gastritis. In the current study, we hypothesize that somatostatin acts directly on antigen-presenting cells in the stomach to lessen the severity of gastritis. To test this hypothesis, we first show that CD11c+ dendritic cells are present in the infected tissue of mice with H. pylori-induced gastritis. Pretreatment of bone marrow-derived dendritic cells with somatostatin results in decreased IL-12 production, and lower splenocyte proliferation induced by H. pylori-stimulated dendritic cells. Furthermore, octreotide, a somatostatin analogue, is more potent than somatostatin in suppressing IL-12 release by H. pylori-stimulated dendritic cells through an NF-kappaB-independent pathway. In addition, IL-4 stimulates somatostatin secretion from dendritic cells. In conclusion, somatostatin inhibits dendritic cell activation by H. pylori; a possible mechanism by which IL-4 mediates resolution of gastritis. We suggest that octreotide may be effective in treating immune-mediated diseases of the stomach.

PMID: 16375983 [PubMed - as supplied by publisher]

Again, it may be good at inhibiting PIK3 but bad at suppressing Il 12 release

but the mechanism for IL12 release from dendritic cells may be different when the stimulus is a bacteria like H pylori than cancer.

The danger of oversimplification...but then again, it might be useful...