HER2 Support Group Forums - View Single Post - Attempting to increase rate of Herceptin efficacy,decrease rate of Hercptn resistance

RobinP · 02-06-2006, 12:01 PM

Gina, interesting explanations on why declining estrogen stimulates her2. However, wouldn't you say that just before menopause, one often has imbalanced menstrual cycles with increased estrogen levels as well as decreased estrogen levels?

If you want to state that her2 is some evolutionary mechanism for death, then I would maintain that increased estrogen is what is turning that mechanism on, not decreased estrogen levels. Also, please explain to me why so many young people have her2+ bc as opposed to older women if declining estrogen levels causes her2 stimulation.

Gina, would you ever consider HRT when you become menopausal with natural estradiol and progesterone since you are so concerned about declining estrogen stimuating her2?

02-06-2006, 12:01 PM	#30
RobinP Senior Member Join Date: Nov 2005 Posts: 943	Gina, interesting explanations on why declining estrogen stimulates her2. However, wouldn't you say that just before menopause, one often has imbalanced menstrual cycles with increased estrogen levels as well as decreased estrogen levels? If you want to state that her2 is some evolutionary mechanism for death, then I would maintain that increased estrogen is what is turning that mechanism on, not decreased estrogen levels. Also, please explain to me why so many young people have her2+ bc as opposed to older women if declining estrogen levels causes her2 stimulation. Gina, would you ever consider HRT when you become menopausal with natural estradiol and progesterone since you are so concerned about declining estrogen stimuating her2? __________________ Robin 2002- dx her2 positive DCIS/bc TX Mast, herceptin chemo Last edited by RobinP; 02-06-2006 at 12:23 PM..