[RobinP]

Gina, I find your post interesting as always. However, I disagree with you respectivefully on several points.

First, your theory on female ancestry with early death from declining female estrogen is novel and questionable in my mind. I agree with Lani's interpretation about the importance of ancient female extended life expectancy rather than early death from declining female estrogen.

Additionally, I believe what activates the her2 receptor is a hyperactive estrogen state, as opposed to a declining one. Once estrogen is over stimulated, it is scientifically known that the G cycle in cellular transcription is over activated. Once this occurs, her2 can be activated, eliminating estrogen as the driver to tumor growth. I doubt very much that menopause negatively impacts on her2 bc.

Nonetheless, I appreciate you sharing your personal experiences which are always interesting with your experience in living with advanced her2 bc. Additionally, I also welcome a difference in opinion. If we all thought the same here, what would be the use of our communication anyway? Take care Gina.

PS. I too feel cheated with breast cancer in many ways. Sorry you didn't get the daughter, you so desired.