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Herceptin and the heart
Dr. Slamon quotes a study which shows that herceptin, especially in combination with anthracyclines causes dilative cardiomyopathy (that involves both sides of the heart) and is related to mitochondrial dysfunction and vacuolization of the heart muscle(holes form within the substance of the muscle cells) itself. There is a whole body of literature on herceptin's effects on the heart. Just use either Google or PubMed and put in heart and Herceptin. The truth, as usual, is that there is a lot more that isn't known than is known. But it IS an area of active interest.
Hope this helps!
Lani
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